PNH and the GPI-Linked Proteins
Neal S. Young (Editor), Joel Moss (Editor)
Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients.Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins.This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins. Key Features* Outlines the chemical features of PNH* Explains the mechanism of hemolysis* Includes work on the biochemistry of glycophosphoinositol anchors* Contains descriptions of the chemistry and biophysics of GPI-anchored proteins
Kategorien:
Jahr:
2000
Auflage:
1
Verlag:
Academic Press
Sprache:
english
Seiten:
293
ISBN 10:
0127729402
ISBN 13:
9780127729404
Datei:
PDF, 6.10 MB
IPFS:
,
english, 2000